Overblog
Editer l'article Suivre ce blog Administration + Créer mon blog
17 février 2010 3 17 /02 /février /2010 09:35

(verbatim)


L'article scientifique original du 17 février 2010 sur la parenté de Toutankhamon


Accès payant ou réseau à l'article en entier :
http://jama.ama-assn.org/cgi/reprint/303/7/638

Principales informations contenus dans l'article ici :
http://forum.egyptiandreams.co.uk/viewtopic.php?t=4848


Abstract :
http://jama.ama-assn.org/cgi/content/short/303/7/638

Vol. 303 No. 7, February 17, 2010     JAMA 
  •  Online Features 
 
   Original Contribution  
    This Article
 • Full text
 • PDF
 • eSupplement
 • Interactive feature
 • Send to a friend
 • Save in My Folder
 • Save to citation manager
 • Permissions
 
   Citing Articles
 • Citing articles on HighWire
 • Contact me when this article is cited
 
Related Content
 • Related article
 
 • Similar articles in JAMA

  Topic Collections
 • Neurology
 • Neurogenetics
 • Movement Disorders
 • Rheumatology
 • Musculoskeletal Syndromes (Chronic Fatigue, Gulf War)
 • Malaria
 • Genetics
 • Genetic Disorders
 • Humanities
 • History of Medicine
 • Infectious Diseases
 • Alert me on articles by topic
 
  Social Bookmarking
          What's this? 

Ancestry and Pathology in King Tutankhamun's Family
Zahi Hawass, PhD; Yehia Z. Gad, MD; Somaia Ismail, PhD; Rabab Khairat, MSc; Dina Fathalla, MSc; Naglaa Hasan, MSc; Amal Ahmed, BPharm; Hisham Elleithy, MA; Markus Ball, MSc; Fawzi Gaballah, PhD; Sally Wasef, MSc; Mohamed Fateen, MD; Hany Amer, PhD; Paul Gostner, MD; Ashraf Selim, MD; Albert Zink, PhD; Carsten M. Pusch, PhD


JAMA. 2010;303(7):638-647.

Context  The New Kingdom in ancient Egypt, comprising the 18th, 19th, and 20th dynasties, spanned the mid-16th to the early 11th centuries BC. The late 18th dynasty, which included the reigns of pharaohs Akhenaten and Tutankhamun, was an extraordinary time. The identification of a number of royal mummies from this era, the exact relationships between some members of the royal family, and possible illnesses and causes of death have been matters of debate.

Objectives  To introduce a new approach to molecular and medical Egyptology, to determine familial relationships among 11 royal mummies of the New Kingdom, and to search for pathological features attributable to possible murder, consanguinity, inherited disorders, and infectious diseases.

Design  From September 2007 to October 2009, royal mummies underwent detailed anthropological, radiological, and genetic studies as part of the King Tutankhamun Family Project. Mummies distinct from Tutankhamun's immediate lineage served as the genetic and morphological reference. To authenticate DNA results, analytical steps were repeated and independently replicated in a second ancient DNA laboratory staffed by a separate group of personnel. Eleven royal mummies dating from circa 1410-1324 BC and suspected of being kindred of Tutankhamun and 5 royal mummies dating to an earlier period, circa 1550-1479 BC, were examined.

Main Outcome Measures  Microsatellite-based haplotypes in the mummies, generational segregation of alleles within possible pedigree variants, and correlation of identified diseases with individual age, archeological evidence, and the written historical record.

Results  Genetic fingerprinting allowed the construction of a 5-generation pedigree of Tutankhamun's immediate lineage. The KV55 mummy and KV35YL were identified as the parents of Tutankhamun. No signs of gynecomastia and craniosynostoses (eg, Antley-Bixler syndrome) or Marfan syndrome were found, but an accumulation of malformations in Tutankhamun's family was evident. Several pathologies including Köhler disease II were diagnosed in Tutankhamun; none alone would have caused death. Genetic testing for STEVOR, AMA1, or MSP1 genes specific for Plasmodium falciparum revealed indications of malaria tropica in 4 mummies, including Tutankhamun’s. These results suggest avascular bone necrosis in conjunction with the malarial infection as the most likely cause of death in Tutankhamun. Walking impairment and malarial disease sustained by Tutankhamun is supported by the discovery of canes and an afterlife pharmacy in his tomb.

Conclusion  Using a multidisciplinary scientific approach, we showed the feasibility of gathering data on Pharaonic kinship and diseases and speculated about individual causes of death.


Author Affiliations: Supreme Council of Antiquities, Cairo, Egypt (Dr Hawass and Mr Elleithy); National Research Center, Cairo, Egypt (Drs Gad, Ismail, and Amer and Mss Hasan and Ahmed); Ancient DNA Laboratory, Egyptian Museum, Cairo, Egypt (Drs Gad and Ismail and Mss Fathalla, Khairat, Hasan, and Ahmed); Institute of Human Genetics, Division of Molecular Genetics, University of Tübingen, Tübingen, Germany (Ms Khairat, Mr Ball, and Dr Pusch); Learning Resource Center, Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt (Drs Gaballah and Fateen and Ms Wasef); Department of Radiodiagnostics, Central Hospital Bolzano, Bolzano, Italy (Dr Gostner); Department of Radiology, Kasr Al Ainy Faculty of Medicine, Cairo, Egypt (Dr Selim); and Institute for Mummies and the Iceman, EURAC, Bolzano, Italy (Dr Zink).



 CiteULike    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter     What's this?


RELATED ARTICLE 


King Tutankhamun, Modern Medical Science, and the Expanding Boundaries of Historical Inquiry
Howard Markel
JAMA. 2010;303(7):667-668.
EXTRACT | FULL TEXT  



THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES 


King Tutankhamun, Modern Medical Science, and the Expanding Boundaries of Historical Inquiry
Markel
JAMA 2010;303:667-668.
FULL TEXT  
http://jama.ama-assn.org/cgi/content/full/303/7/667
http://jama.ama-assn.org/cgi/reprint/303/7/638
 





Partager cet article
Repost0

commentaires

Résultats officiels
de l'élection présidentielle 2012
 


Pour mettre la page en PDF :
Print


 




Petites statistiques
à titre informatif uniquement.

Du 07 février 2007
au 07 février 2012.


3 476 articles publiés.

Pages vues : 836 623 (total).
Visiteurs uniques : 452 415 (total).

Journée record : 17 mai 2011
(15 372 pages vues).

Mois record : juin 2007
(89 964 pages vues).